Not arguing against that - snuff is awful. Which is a bit different because then we are talking about combustion of cigarettes, products made from that combustion, byproducts with additives, and the metabolism associated with cigarettes as a whole - not just nicotine.Д¬itation found Here is with snuff and revolves around oral cancer with snuff. It's primarily about tobacco statistics - not at particularly relevant.Д¬itation found Here is almost entirely about smoking and patient exposure to smoke. Referencing the text the study doesn't mention nAChRs really. I'll probably add to this when I have time but a few things:Д¬itation is a dead link. Ever wonder why the vaping bans never include cigarettes? A lot of researchers get paid money to research tobacco and have put their whole careers in it - they need money to continue doing research - they have a vested interest in certain things too. A lot of states get money from tobacco tax, which goes away if you have e-cigarettes, because they aren't part of that tax settlement.

This is a very very very very complex research field. And again, you need to show safety to pass the regulatory application. If you allow people to play with that you potentially lose all of the benefits of that control. Vaporizers are good because they control temperature at a certain level which prevents most if not all of the harmful byproducts of combustion from forming. Some of these systems also allow you to adjust voltage. That's a very very very very very brief explanation of why. Which makes it more likely you're going to have more addiction to nicotine. Which increases the likelihood that non smokers and former smokers will find it interesting. And giving people the opportunity to do all these things. We're dealing with addiction here and addicts will self-dose if you let them. And the FDA isn't exactly keen on people doing some of the above. Next year it's illegal to sell these devices without an application.

Now your motorcycle point is only sort of correct. So they could potentially (some already do) put illicit substances in their liquids, they could start mixing liquids, they could increase the nicotine concentration by a lot, and so forth. Well first, people can start putting whatever they want into their e-liquids if its open. So why do 'mods' or 'open' systems have problems? If you successfully show this, with scientific data, there's a chance the FDA will let you continue selling (but not allow you to make any claims about being safer - that's an entirely different application called an MRTP). Some more stuff around safety, mostly standard. They will not cause people who have already quit smoking to come back and start using their product They will not cause additional harm to the population They will not attract people who don't already smoke, to try their product (This is a big one) They will attract cigarette smokers to stop smoking What's this mean? It means any company that wants to sell product after next year + however long it takes the FDA to review their application needs to show the following: They have to go through an application process to show that they are 'Appropriate for the Protection of Public Health'. Okay so cigarettes are grandfathered into the regulations. Which is why pretty soon none of the companies can do marketing campaigns anymore and aren't allowed to tout any benefit of their product (regardless of the truth behind the claim - this is why the big companies aren't saying anything or helping pro-vaping groups anymore). They don't know what to do with this new technology so they say 'Hey it's close enough lets apply the same regulations'. Complicated to answer this on a forum post so cliff notes maybe.

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